|Atheris Analytical - Mass spectrometry Biochemistry Protein engineering Metabolic studies|
|Atheris Discovery - Venoms to drugs Venoms database Lead discovery Early development Biomarkers|
Once a lead compound is selected for further evaluation, optimization and formulation, a series of investigations is undertaken to scrutinize its PK, PD, Toxicity and Efficacy properties. These investigations have to yield a clear picture of the PK-LADME (Liberation, Absorption, Degradation, Metabolism and Excretion), Toxicity and Pharmacology profile.
Don't Stop Me Now !
At Atheris we put our expertise to work to help our partners in various stages of the drug development process. For instance, we undertake investigations that can be integrated in the:
Whether as part of a full study confided to Atheris or as a stand-alone service, we perform custom-designed and highly reliable investigations in several areas. This completes the lead discovery cycle of investigations and allows the selection of lead candidates for the early development stage of the drug discovery process.
Our original approach also includes the screening for natural analogues of selected lead compounds. In most cases, a lead compound will belong to a structural family, of which many analogues designed by Nature can be identified in similar samples. This allows drawing a map of analogues and identify key structural signatures and positions that undergo a higher rate of mutations. This information if of great assistance to drug design strategies, to give clues for lead optimization. Our approach is thus again based on parallel strategies and involves:
The stability of the lead compound is crucial. To evaluate this, we use HPLC and mass spectrometry for a sensitive follow-up, detection, identification and quantification of degradation products over time under various conditions.
PK-LADME Pharmacokinetic and metabolic studies
Based on our analytical capacities, we also willingly assist early stage development, for example through:
Again we can assist toxicity studies through an array of analytical studies: