A unique platform dedicated to lead discovery and optimization
Decades of expertise in purification, structural characterization and synthesis of peptides, proteins and other natural lead candidates
Peptide and protein biochemistry
Over the years Atheris SA has built a unique, world-class expertise pertaining to the extraction, purification, and structural elucidation of biomolecules. Our equipment includes chromatographic systems (HPLC and FPLC), electrophoresis, UV/VIS and fluorescence spectrophotometery and Edman sequencing.
Mass spectrometry, peptidomics and proteomics
We use a complementary set of high technology instruments of the latest generation to offer a wide range of MS analyses: from routine ESI-MS or MALDI-TOF-MS analyses, via identification of proteins isolated from 2D SDS-PAGE gels, to de novo nanoLC-MS/MS sequencing for α- and β-Melusine hit deconvolution.
NextGen sequencing dedicated to venom glands transcriptomics
Having pioneered Venomics back in 2003, we established the first sequencing platformm devoted to massive venom gland mRNA sequencing using NextGen strategies (RNA-Seq). These sequences feed our γ-Melusine databases and dedicated algorithms allow-us to speed-up lead candidate identification.
High-throughput multiplex peptide synthesis
We have developed a state-of-the-art multiplex synthesis platform to produce hundreds of peptides and mini-proteins (up to 60 residues) with disulfide bonds (up to 4) in parallel. These are desalted, refolded and dispensed in δ-Melusine microplates for medium to high-throughput bioactivity screening.