A unique three-pronged approach inspired by Nature
Natural Peptides to Drugs
Atheris has pioneered structure-driven and biocomputing-assisted Venomics drug discovery strategies.
The venom itself is pre-fractionated to generate a “natural library” of compounds, and hits arising from bioassays are submitted to peptidomic analyses. The deconvolution process to identify the bioactive in fractions of the natural library is facilitated by the use of proprietary bioinformatic tools to match mass spectra against public and proprietary protein, EST and genome databases.
Our strategy further allows identifying natural analogues of hits, instrumental information for structure-activity studies and lead optimisation. Novelty, relevance and drugability of hits are similarly evaluated at an early stage for lead selection.