Laboratories

PROLAB

A unique platform dedicated to lead discovery and optimization

Decades of expertise in purification, structural characterization and synthesis of peptides, proteins and other natural lead candidates

BIO PROLAB

PEPTIDE AND PROTEIN BIOCHEMISTRY

Over the years Atheris SA has built a unique, world-class expertise pertaining to the extraction, purification, and structural elucidation of biomolecules. Our equipment includes chromatographic systems (HPLC and FPLC), electrophoresis, UV/VIS and fluorescence spectrophotometery and Edman sequencing.

MS PROLAB

MASS SPECTROMETRY, PEPTIDOMICS AND PROTEOMICS

We use a complementary set of high technology instruments of the latest generation to offer a wide range of MS analyses: from routine ESI-MS or MALDI-TOF-MS analyses, via identification of proteins isolated from 2D SDS-PAGE gels, to de novo nanoLC-MS/MS sequencing for α- and β-Melusine hit deconvolution.

NGS PROLAB

NEXTGEN SEQUENCING DEDICATED TO VENOM GLANDS TRANSCRIPTOMICS

Having pioneered Venomics back in 2003, we established the first sequencing platformm devoted to massive venom gland mRNA sequencing using NextGen strategies (RNA-Seq). These sequences feed our γ-Melusine databases and dedicated algorithms allow-us to speed-up lead candidate identification.

SYNT PROLAB

HIGH-THROUGHPUT MULTIPLEX PEPTIDE SYNTHESIS

We have developed a state-of-the-art multiplex synthesis platform to produce hundreds of peptides and mini-proteins (up to 60 residues) with disulfide bonds (up to 4) in parallel. These are desalted, refolded and dispensed in δ-Melusine microplates for medium to high-throughput bioactivity screening.